Please use this identifier to cite or link to this item: https://dr.ddn.upes.ac.in//xmlui/handle/123456789/1901
Title: Study of some benzimidazole compounds as antibacterial and antifungal agent
Authors: Arora, Shefali
Keywords: Antibacterail Activity
Issue Date: 2011
Citation: Journal of pharmaceutical sciences and research 3(7), 2011; pp.1310-1314
Abstract: There is a clinical need for new treatment option as a result of continued increase in the expression of resistance among bacterial and fungal pathogens. A number of compounds currently in development show promise. However, in some cases, there is concern that resistance may develop quickly to new compounds that are based on existing antimicrobial agents. So it is therefore desirable to develop new potent antifungal, antibacterial drugs which produces minimum or no side effect and low cost. In continuation of this studies, some benzimidazole derivatives have been prepared and screened their antimicrobial activities with various strains. Various benzimidazole derivative of o-phenylene diamine, 4,5-dimethyl-1,2-phenylene diamine, 4-chloro-1,2-phenylenediamine, 3,4- diaminobenzophenone and S-methylated 3,4-diaminobenzophenone have been prepared by the reaction of 4-isothiocyanato-4-methyl pentan-2-one. All synthesized derivatives have been screened with the various bacterial and fungal strains viz. Escherichia coli, Bacillus pumilus, Micrococcus luteus, Bacillus cereus, Klebsiella pneumonaie, Aspergillus niger, Aspergillus flavus, Trichosporum flavurusclem and Microsporum gypseum. After the antimicrobial studies, it were found that the S-methylated 3,4-diamino benzophenone derivative (V) acts as a standard drug against bacterial strain Klebsiella pneumonaie and all tested fungal strains, because it showed more inhibition zone than the standard drug Amoxycillin and Ketoconazole respectively.
URI: http://hdl.handle.net/123456789/1901
Appears in Collections:Published papers

Files in This Item:
File Description SizeFormat 
publishedjpsr.pdf535.59 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.